mGIST Cancer RoadMap – Say YES to HOPE

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Home
About Us
Advanced Cancer
- Cancer Type
  - Bladder
  - Brain
  - Breast
  - Cervical
  - Colorectal
  - Esophageal
  - GIST
  - Liver
  - Lung
  - Melanoma
  - Neuroendocrine
  - Ovarian
  - Pancreatic
  - Prostate
  - Renal Cell
- If Cancer Spreads
Support

Metastatic Gastric (Stomach) Cancer Roadmap

Understanding your diagnosis, tumor biology, and treatment history can help guide conversations with your care team and help you explore available options.

1. Diagnosis & Cancer History

What type of stomach cancer were you diagnosed with? Where in the stomach did the cancer begin? When was metastatic or recurrent disease diagnosed? Before metastatic disease was diagnosed, did you receive any of the following treatments?

Surgery (gastrectomy) Radiation therapy Chemotherapy Chemoradiation None Not sure

Have lymph nodes been involved? Where did the cancer first spread?

2. Tumor Biomarkers & Molecular Testing

Has your tumor been tested for any of the following?

HER2 amplification or overexpression PD-L1 expression MSI-High / mismatch repair deficiency (dMMR) Tumor mutational burden (TMB) CLDN18.2 expression FGFR alteration NTRK gene fusion EBV (Epstein-Barr Virus) positive tumor Other genomic mutation identified No mutations identified Not sure

Has comprehensive genomic testing been performed?

3. Where Has the Cancer Spread?

Lymph nodes Liver Peritoneum (abdominal lining) Lung Bone Other organs Not sure

Liver Metastases

How many tumors are in the liver? Have treatments aimed specifically at the liver been discussed?

Surgery Focused radiation therapy Tumor-directed treatment Medication treatment only Not sure

Peritoneal Metastases

Has cancer spread to the lining of the abdomen (peritoneum)? How has this been described? Have treatments aimed at abdominal disease been discussed?

Surgery Tumor-directed treatment Medication treatment only Not sure

Lung Metastases

How many tumors are in the lungs? Have treatments aimed specifically at lung tumors been discussed?

Surgery Focused radiation therapy Tumor-directed treatment Medication treatment only Not sure

Bone Metastases

How many areas of bone are affected? Have treatments aimed directly at bone metastases been discussed?

Radiation therapy Bone-strengthening medications Surgery to stabilize a bone lesion Medication treatment only Not sure

4. Treatment Goals & Planning

What has your care team described as the primary goal of treatment right now? Have doctors discussed whether treatments aimed directly at specific tumors might be possible?

Examples may include:
• surgery to remove tumors
• focused radiation therapy
• other tumor-directed treatments recommended by your care team

How will your doctors evaluate whether treatment is working?

Imaging scans (CT, PET, MRI) Blood tests or tumor markers Symptom improvement Not sure

How often are scans or evaluations planned?

5. Prior Systemic Treatments

Chemotherapy

FOLFOX CAPOX (XELOX) FLOT Cisplatin-based chemotherapy Carboplatin-based chemotherapy Paclitaxel Docetaxel Irinotecan Other chemotherapy Not sure

Targeted Therapy

Trastuzumab (Herceptin) Trastuzumab deruxtecan (Enhertu) Zolbetuximab (for CLDN18.2 tumors) Ramucirumab (Cyramza) Other targeted therapy Not sure

Immunotherapy

Pembrolizumab (Keytruda) Nivolumab (Opdivo) Other immunotherapy Not sure

Tumor-Agnostic Targeted Therapies

NTRK-targeted therapy Other genomic-targeted therapy Not sure

Clinical Trial Treatments Are you currently receiving treatment?

Chemotherapy Targeted therapy Immunotherapy Clinical trial Not currently receiving treatment Not sure

6. Prior Local Treatments

Surgery

Stomach tumor surgery (gastrectomy) Surgery to remove metastatic tumors Other surgery No surgery

Radiation

Radiation to the stomach Radiation to metastatic tumors Focused radiation therapy Not sure

Other Tumor-Directed Treatments

Tumor-directed procedure Other procedure None

7. Your Health, Priorities & Questions

How are you feeling in daily life? Are you experiencing symptoms you would like help managing?

Difficulty eating Weight loss Fatigue Pain Nausea or vomiting Other symptoms None currently

What matters most to you right now? Important things your care team should know My Questions for My Care Team

Final Note: This roadmap is designed to help patients understand their diagnosis and prepare for conversations with their care team. It does not replace medical advice.

About You (Optional)

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Age Range Race / Ethnicity

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Cancer Roadmap

Physician Discussion Summary

For Informational Purposes Only – Not Medical Advice

The information provided by this tool is intended for educational and informational purposes only. This tool does not provide medical advice, professional diagnosis, opinion, or treatment to you or any other individual.

Consult Your Physician: This information is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.
No Doctor-Patient Relationship: Your use of this tool does not create a doctor-patient relationship between you and “Say YES to Hope” or any associated clinical partners.
Emergency Situations: Never disregard professional medical advice or delay in seeking it because of something you have read in this roadmap. If you think you may have a medical emergency, call your doctor or emergency services immediately.
Accuracy of Information: We strive to use the latest resources for our information but medical knowledge is constantly evolving. “Say YES to Hope” does not guarantee the accuracy, completeness, or timeliness of the information generated.

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