mBrain Cancer RoadMap – Say YES to HOPE

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Home
About Us
Advanced Cancer
- Cancer Type
  - Bladder
  - Brain
  - Breast
  - Cervical
  - Colorectal
  - Esophageal
  - GIST
  - Liver
  - Lung
  - Melanoma
  - Neuroendocrine
  - Ovarian
  - Pancreatic
  - Prostate
  - Renal Cell
- If Cancer Spreads
Support

Metastatic Brain Cancer Roadmap

Understanding your diagnosis, tumor biology, and treatment history can help guide conversations with your care team and help you explore available options.

1. Diagnosis & Cancer History

What type of primary brain tumor were you diagnosed with? What grade was the tumor? When was the tumor first diagnosed? Where in the brain did the tumor begin? What symptoms led to diagnosis?

Seizures Headaches Vision changes Weakness or coordination problems Speech difficulty Memory or cognitive changes Other symptoms No symptoms

2. Tumor Biomarkers & Molecular Testing

Molecular testing helps guide treatment planning.

Has molecular testing been performed on the tumor? If testing was performed, were any of the following identified?

IDH mutation MGMT promoter methylation 1p/19q co-deletion TERT mutation BRAF mutation Other mutation No mutations identified Not sure

Has comprehensive genomic testing been performed?

3. Tumor Characteristics

How many tumors are present? Has the tumor spread to other areas of the brain? Has the tumor spread to the spinal cord or spinal fluid? Has imaging shown tumor growth or recurrence?

Possible tumor-directed treatments your care team may discuss:
• surgical tumor removal
• stereotactic radiosurgery
• external beam radiation therapy
• proton therapy
• laser interstitial thermal therapy

4. Prior Systemic Treatments

Treatments that travel throughout the body.

Chemotherapy

Temozolomide (Temodar) Lomustine (CCNU) PCV chemotherapy regimen (Procarbazine, Lomustine, Vincristine) Carmustine (BCNU) Other chemotherapy Not sure

Targeted Therapy

Bevacizumab (Avastin) BRAF-targeted therapy Other targeted therapy Not sure

Immunotherapy

Pembrolizumab (Keytruda) Nivolumab (Opdivo) Other immunotherapy Not sure

Tumor Treating Fields Clinical Trial Treatments Are you currently receiving treatment?

Chemotherapy Targeted therapy Immunotherapy Tumor Treating Fields Clinical trial treatment Not currently receiving treatment Not sure

5. Prior Brain-Directed Treatments

What type of surgery was performed? Has imaging shown tumor remaining after surgery? Radiation Therapy

External beam radiation therapy Focused stereotactic radiosurgery (SRS) Fractionated stereotactic radiation therapy Proton therapy Whole brain radiation therapy No radiation therapy Not sure

Examples of focused stereotactic radiosurgery:
• Gamma Knife
• CyberKnife
• LINAC stereotactic radiosurgery

Radiation Implants

GammaTile therapy (cesium-131 radiation tiles placed during surgery) Other radiation implant therapy None Not sure

Other Tumor-Directed Treatments

Laser Interstitial Thermal Therapy (LITT) Tumor Treating Fields (Optune) Other procedure None

6. Your Health, Priorities & Questions

How are you feeling in daily life? Are you experiencing symptoms you would like help managing?

Headaches Seizures Memory or cognitive changes Balance problems Weakness Fatigue Other symptoms None currently

Are you taking medications to help manage symptoms? What matters most to you right now? Important things your care team should know My Questions for My Care Team

Final Note: This roadmap is designed to help patients understand their diagnosis and prepare for conversations with their care team. It does not replace medical advice.

About You (Optional)

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Age Range Race / Ethnicity

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Cancer Roadmap

Physician Discussion Summary

For Informational Purposes Only – Not Medical Advice

The information provided by this tool is intended for educational and informational purposes only. This tool does not provide medical advice, professional diagnosis, opinion, or treatment to you or any other individual.

Consult Your Physician: This information is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.
No Doctor-Patient Relationship: Your use of this tool does not create a doctor-patient relationship between you and “Say YES to Hope” or any associated clinical partners.
Emergency Situations: Never disregard professional medical advice or delay in seeking it because of something you have read in this roadmap. If you think you may have a medical emergency, call your doctor or emergency services immediately.
Accuracy of Information: We strive to use the latest resources for our information but medical knowledge is constantly evolving. “Say YES to Hope” does not guarantee the accuracy, completeness, or timeliness of the information generated.

The information presented in this Website is not intended as a substitute for medical care. Please talk with your healthcare provider about any information you get from this Website.

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