Say YES to HOPE

TOLL FREE
SURVIVOR LINE
1-877-937-7478

Donate Button
← Back
mCRC Roadmap

1. Diagnosis History

Where did the cancer start? How was metastatic disease discovered? Timing of Metastatic Diagnosis

2. Tumor Biology, Biomarkers & Genetic Testing

Understanding biomarker and genetic testing can help guide treatment decisions and identify potential treatment options.

Colorectal Cancer Biomarkers

How your cancer may be classified

Metastatic colorectal cancer is often evaluated using biomarkers found in the tumor.

Has your cancer been tested for any of the following?
Your cancer may be described as:
Why this matters:
  • MMR / MSI testing helps identify cancers that may respond to immunotherapy
  • KRAS and NRAS results help determine whether EGFR-targeted therapy may be useful
  • BRAF, HER2, and NTRK may identify targeted treatment options

2A. Inherited (Germline) Genetic Testing

“What I was born with”

These are genetic changes you are born with and may run in families.

Has germline genetic testing been performed?
Why this matters:
  • may identify inherited cancer risk
  • may explain why colorectal cancer developed
  • may help guide treatment, surveillance, and family testing
  • may identify eligibility for clinical trials

2B. Tumor (Somatic) Genetic Testing

“What changed in the cancer”

These are genetic changes found in the cancer itself and are not inherited.

Has tumor genomic testing been performed?
Why this matters:
  • helps match targeted therapies
  • may determine eligibility for immunotherapy
  • may help determine whether EGFR-targeted therapy is likely to work
  • may guide clinical trial options

2C. Advanced Blood-Based Testing (Liquid Biopsy)

These tests look for cancer signals in the bloodstream.

Have doctors discussed blood-based cancer testing?
What these tests may help with:
  • identifying tumor mutations from a blood sample
  • monitoring treatment response
  • detecting cancer signals in the bloodstream
  • checking for recurrence or changes over time

These tests are evolving and may not be appropriate for every situation.

Do Test Results Change Over Time?

Cancer can change over time, and repeat testing may sometimes be recommended.

Has repeat testing been discussed?
Repeat testing may help:
  • identify new mutations
  • guide next treatment options
  • reassess tumor biology as the cancer evolves

Summary

  • MMR / MSI testing is important in colorectal cancer
  • Germline testing looks for inherited risk
  • Tumor testing looks for changes in the cancer itself
  • Blood-based testing may help monitor disease or identify mutations over time

Together, these results help your care team guide treatment decisions and explore potential options.

3. Where has the cancer spread?

Select all areas you have been told about.

Other Sites (Not Listed) Where is most of the cancer currently located? Have your scans been reviewed by doctors who specialize in treating cancer that has spread?

4. Treatment History

Select any treatments you have received.

Chemotherapy
Targeted Therapies
Immunotherapy
Later-Line Treatments
Did any treatment shrink your tumors significantly? Are you currently receiving treatment?
Prior Local Treatments (Treatments aimed at specific tumors) Surgery
Radiation Treatments
Tumor-Directed Treatments

5. Your Health, Priorities, and Questions

This helps your care team understand how treatment may affect you.

How are you feeling in your daily life? Which of these best reflects your priorities at this time? Would you like to explore clinical trial possibilities? Based on the information you entered in this roadmap, what questions or concerns would you like to discuss with your doctor?

About You (Optional)

You can skip this section. It helps us understand who is using this tool in aggregate.

Generate Physician Discussion Summary

When ready, generate a formatted report that can be printed or saved as a PDF.

For Informational Purposes Only – Not Medical Advice

The information provided by this tool is intended for educational and informational purposes only. This tool does not provide medical advice, professional diagnosis, opinion, or treatment to you or any other individual.
  • Consult Your Physician: This information is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.
  • No Doctor-Patient Relationship: Your use of this tool does not create a doctor-patient relationship between you and “Say YES to Hope” or any associated clinical partners.
  • Emergency Situations: Never disregard professional medical advice or delay in seeking it because of something you have read in this roadmap. If you think you may have a medical emergency, call your doctor or emergency services immediately.
  • Accuracy of Information: We strive to use the latest resources for our information but medical knowledge is constantly evolving. “Say YES to Hope” does not guarantee the accuracy, completeness, or timeliness of the information generated.