mProstate Cancer RoadMap – Say YES to HOPE

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Advanced Cancer
- Cancer Type
  - Bladder
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- If Cancer Spreads
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Metastatic Prostate Cancer Roadmap

Understanding your diagnosis, tumor biology, and treatment history can help guide conversations with your care team and help you explore available options.

1. Diagnosis & Cancer History

When were you first diagnosed with prostate cancer? What stage was your cancer when metastatic disease was identified? What was your Gleason score or Grade Group? Was the prostate surgically removed? Have you received radiation to the prostate? Were lymph nodes involved?

2. Tumor Biology & Biomarkers

Has genetic testing been performed? Germline mutations

BRCA1 BRCA2 ATM CHEK2 PALB2 HOXB13 Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2) Other germline mutation Not sure

Tumor (somatic) mutations

BRCA mutation ATM mutation CDK12 mutation PTEN loss TP53 mutation SPOP mutation MSI-High / mismatch repair deficiency Tumor mutational burden (TMB) Other mutation identified No mutations identified Not sure

Imaging

PSMA PET scan Conventional PET scan CT scan MRI Bone scan Not sure

Tumor markers monitored

PSA (Prostate-Specific Antigen) Alkaline phosphatase Lactate dehydrogenase (LDH) Other marker Not sure

3. Where Has the Cancer Spread?

Select all areas identified.

Bone Lymph nodes Liver Lung Brain Adrenal glands Peritoneum / abdominal lining Pleura (lining around lungs) Skin or soft tissue Spine / spinal cord involvement Other organs Not sure

Bone Metastases

How many areas of bone are affected? Treatments discussed?

Radiation therapy Bone-strengthening medications (zoledronic acid, denosumab) Surgery to stabilize bone Radiopharmaceutical therapy Medication treatment only Not sure

Lymph Node Metastases

Which lymph nodes are involved?

Pelvic lymph nodes Retroperitoneal lymph nodes Distant lymph nodes Not sure

Liver Metastases

How many tumors are present?

Lung Metastases

How many tumors are present?

Brain Metastases

Has cancer spread to the brain? Treatments discussed?

Surgery Stereotactic radiosurgery Whole brain radiation Medication treatment only Not sure

Spinal Cord Involvement

Have doctors discussed spinal cord compression?

Symptoms may include severe back pain, weakness in the legs, difficulty walking, or bladder / bowel changes.

4. Hormone-Sensitive vs Castration-Resistant Pathway

Has hormone therapy been started? Doctors may describe prostate cancer as:

Metastatic hormone-sensitive prostate cancer (mHSPC) Metastatic castration-resistant prostate cancer (mCRPC) Not sure

Why this matters:

mHSPC discussions often focus on starting or intensifying androgen deprivation therapy.
mCRPC discussions often focus on next-line hormone therapy, chemotherapy, radioligand therapy, targeted therapy, or clinical trials.

5. Prior Systemic Treatments

Androgen deprivation therapy (ADT)

Leuprolide (Lupron) Goserelin (Zoladex) Degarelix Relugolix Orchiectomy Not sure

Androgen receptor targeted therapy

Abiraterone (Zytiga) Enzalutamide (Xtandi) Apalutamide (Erleada) Darolutamide (Nubeqa) Other hormone therapy Not sure

Chemotherapy

Docetaxel Cabazitaxel Other chemotherapy Not sure

Targeted therapy

PARP inhibitor (Olaparib) PARP inhibitor (Rucaparib) Other targeted therapy Not sure

Immunotherapy

Sipuleucel-T (Provenge) Pembrolizumab Other immunotherapy Not sure

Radiopharmaceutical therapy

Radium-223 (Xofigo) Lutetium-177 PSMA therapy (Pluvicto) Other radioligand therapy Not sure

Clinical trials Current treatment

Hormone therapy Chemotherapy Targeted therapy Radioligand therapy Immunotherapy Clinical trial Not currently receiving treatment Not sure

6. Prior Local Treatments

Surgery

Radical prostatectomy Surgery to remove metastatic tumors No surgery

Radiation

Radiation to prostate Radiation to bone metastases Focused radiation therapy (SBRT) Other radiation therapy None

Ablation

Cryotherapy High-intensity focused ultrasound Other procedure Not sure

7. Your Health, Priorities & Questions

How are you feeling in daily life? Symptoms you would like help managing

Bone pain Fatigue Urinary symptoms Weight loss Weakness Shortness of breath Other symptoms None currently

What matters most to you right now?

Questions you may wish to ask your care team

Is my cancer hormone-sensitive or castration-resistant?
Has my tumor been tested for BRCA or other genetic mutations?
Am I eligible for PARP inhibitor therapy?
Should PSMA imaging be performed?
Am I a candidate for radioligand therapy such as Pluvicto?
What is the goal of my treatment right now?

Notes for your care team Are you interested in clinical trial options?

ZIP code How far are you willing to travel?

My questions for my care team

About You (Optional)

You can skip this section. It helps us understand who is using this tool in aggregate.

Age Range Race / Ethnicity

Generate Physician Discussion Summary

This will create a structured roadmap you can review, print, or save as a PDF.

Cancer Roadmap

Physician Discussion Summary

For Informational Purposes Only – Not Medical Advice

The information provided by this tool is intended for educational and informational purposes only. This tool does not provide medical advice, professional diagnosis, opinion, or treatment to you or any other individual.

Consult Your Physician: This information is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.
No Doctor-Patient Relationship: Your use of this tool does not create a doctor-patient relationship between you and “Say YES to Hope” or any associated clinical partners.
Emergency Situations: Never disregard professional medical advice or delay in seeking it because of something you have read in this roadmap. If you think you may have a medical emergency, call your doctor or emergency services immediately.
Accuracy of Information: We strive to use the latest resources for our information but medical knowledge is constantly evolving. “Say YES to Hope” does not guarantee the accuracy, completeness, or timeliness of the information generated.

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