mRenalcell Carcinoma RoadMap – Say YES to HOPE

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Home
About Us
Advanced Cancer
- Cancer Type
  - Bladder
  - Brain
  - Breast
  - Cervical
  - Colorectal
  - Esophageal
  - GIST
  - Liver
  - Lung
  - Melanoma
  - Neuroendocrine
  - Ovarian
  - Pancreatic
  - Prostate
  - Renal Cell
- If Cancer Spreads
Support

Metastatic Renal Cell Carcinoma (Kidney Cancer) Roadmap

Understanding your diagnosis, tumor biology, and treatment history can help guide conversations with your care team and help you explore available options.

1. Diagnosis & Cancer History

What type of kidney cancer were you diagnosed with? Which kidney did the cancer begin in? When was metastatic or advanced disease diagnosed? Was surgery performed to remove the kidney? Was lymph node involvement reported?

2. Tumor Biology & Biomarkers

Has genetic or molecular testing been performed? Has your tumor been tested for any of the following?

VHL mutation PBRM1 mutation BAP1 mutation MET mutation FH mutation TSC1 / TSC2 mutation PTEN mutation MSI-High / mismatch repair deficiency Tumor mutational burden (TMB) Other mutation identified No mutations identified Not sure

Has germline genetic testing been performed? Tumor markers monitored

Blood tests for kidney function LDH Calcium levels Hemoglobin levels Other laboratory markers Not sure

3. Where Has the Cancer Spread?

Select all areas identified.

Lung Bone Liver Lymph nodes Brain Adrenal glands Skin or soft tissue Peritoneum / abdominal lining Other organs Not sure

Lung Metastases

How many tumors are present in the lungs?

Bone Metastases

How many areas of bone are affected? Treatments discussed?

Radiation therapy Bone-strengthening medications Surgery to stabilize bone Medication treatment only Not sure

Liver Metastases

How many tumors are present in the liver?

Brain Metastases

Has cancer spread to the brain? Treatments discussed?

Surgery Stereotactic radiosurgery Whole brain radiation Medication treatment only Not sure

4. Risk Category & Treatment Planning

Doctors may classify metastatic kidney cancer using risk groups.

Has your care team discussed risk category?

IMDC risk model may include factors such as anemia, calcium levels, and time from diagnosis.

What has your care team described as the primary goal of treatment? How will doctors evaluate whether treatment is working?

CT scans MRI scans PET scans Blood tests Symptom improvement Not sure

How often are scans planned?

5. Prior Systemic Treatments

Immunotherapy

Nivolumab (Opdivo) Pembrolizumab (Keytruda) Ipilimumab (Yervoy) Other immunotherapy Not sure

Immunotherapy Combinations

Nivolumab + Ipilimumab Pembrolizumab + Axitinib Pembrolizumab + Lenvatinib Nivolumab + Cabozantinib Avelumab + Axitinib Other combination therapy Not sure

Targeted Therapy (VEGF / TKIs)

Sunitinib (Sutent) Pazopanib (Votrient) Cabozantinib (Cabometyx) Axitinib (Inlyta) Lenvatinib (Lenvima) Sorafenib (Nexavar) Tivozanib (Fotivda) Other targeted therapy Not sure

mTOR Inhibitors

Everolimus (Afinitor) Temsirolimus (Torisel) Not sure

HIF-2a Inhibitor

Belzutifan (Welireg) Not sure

Clinical trials Current treatment

Immunotherapy Targeted therapy Combination therapy Clinical trial Not currently receiving treatment Not sure

6. Prior Local Treatments

Surgery

Radical nephrectomy Partial nephrectomy Surgery to remove metastatic tumors No surgery

Cytoreductive nephrectomy discussed? Radiation

Radiation to metastatic tumors Radiation to brain metastases Focused radiation therapy (SBRT) Other radiation therapy None

Ablation

Radiofrequency ablation Cryoablation Microwave ablation Not sure

7. Your Health, Priorities & Questions

How are you feeling in daily life? Symptoms you would like help managing

Fatigue Pain Shortness of breath Weight loss Loss of appetite Other symptoms None currently

What matters most to you right now? Are you interested in clinical trial options?

ZIP code How far are you willing to travel?

Notes for your care team

Questions you may wish to ask your care team

What subtype of kidney cancer do I have?
What risk category does my cancer fall into?
Am I eligible for immunotherapy combinations?
Should cytoreductive nephrectomy be considered?
Are clinical trials available for my diagnosis?
What is the goal of my treatment right now?

My questions for my care team

About You (Optional)

You can skip this section. It helps us understand who is using this tool in aggregate.

Age Range Race / Ethnicity

Cancer Roadmap

Physician Discussion Summary

For Informational Purposes Only – Not Medical Advice

The information provided by this tool is intended for educational and informational purposes only. This tool does not provide medical advice, professional diagnosis, opinion, or treatment to you or any other individual.

Consult Your Physician: This information is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.
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